Home     Overview    Project tasks     Partners     Results     Jobs     Events      Links    Publications

Scientific publications (click on link where available)

Rimoldi G. Christoffel J. Wuttke W. Morphological findings in uterus, vagina and mammary gland of rats long term treated with oral estradiol or the phytoestrogen genistein. In preparation

Christoffel J., Rimolid G., Wuttke W Effects of 8–prenylnaringenin on the hypothalamo-pituitary-uterine axis in rats after 3 months treatment. J Endocrinology, 2005 in press

Rimoldi, G., Christoffel, J., Wuttke, W. Morphological changes induced by oral 8-prenylnaringenin long-term treatment in uterus, vagina and mammary gland of castrated rats. Menopause, 2005 in press

Seidlová-Wuttke D. Jarry H., Christoffel J., Rimoldi G., Wuttke W. 2005 Comparison of effects of E2 with those of OMC and 4MBC on fat tissue, lipids and pituitary hormones. Tox. Letters in press

Klammer H, Schlecht C, Wuttke W, Jarry H. 2005 Multi-organic risk assessment of estrogenic properties of octyl-methoxycinnamate in vivo A 5-day sub-acute pharmacodynamic study with ovariectomized rats. Toxicology 2005 Aug 18; [Epub ahead of print]

Maerkel, K., Lichtensteiger, W., Durrer, S., Schlumpf, M. (2005) Sex- and region-specific alterations of progesterone receptor mRNA levels and estrogen sensitivity in rat brain following developmental exposure to the estrogenic UV filter 4-methylbenzylidene camphor. Environ. Toxicol. Pharmacol., 19: 761-765.

Durrer, S., Maerkel, K., Schlumpf, M., Lichtensteiger, W. (2005) Estrogen target gene regulation and coactivator expression in rat uterus after developmental exposure to the UV filter 4-methylbenzylidene camphor. Endocrinology 146: 2130-2139. (Commentary pp. 2127-2129)

Seidlová-Wuttke D., Jarry H., Christoffel J., Rimoldi G., Wuttke W. (2005) Comparison of effects of E2 with those of OMC and 4MBC – 2 filters of UV light - on uterine, vaginal and bone parameters. Toxic. App. Pharm

Seidlova-Wuttke, D., Jarry, H., Chrisfoffel, J., Rimoldi, G., Wuttke W. (2005) Effects of Bisphenol-A (BPA), Dibutylphtalate (DBP), Benzophenone-2(BP2), Procymidone (Proc) and Linurone (Lin) on fat tissue, a variety of hormones and metabolic parameters - a 3 months-comparison with effects of estradiol (E2) in ovariectomized (ovx) rats. Toxicology

Gubbay O, Wei G, Rae MT, Niven D, Langdon SP and Hillier SG. (2005) Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas. British Journal of Cancer 92: 1927-33

Hermanussen M, Tresguerres Jaf A new anti-obesity drug treatment: First clinical evidence that antagonising glutamate gated Ca ++ ion channels with memantine normalises binge eating disorders. Economics and Human Biology (3:329-337,2005)

Hermanussen M, Sunder M, Voigt M, Garcia Ap, Salazar V and Tresguerres  JAF Obesity, voracity and short stature: The impact of glutamate in the regulation of appetite. Eur J Clin Nutrition " (in press 2005)

Hamann I, Hofmann P, Schmutzler C, Mentrup B, Huhne K, Jarry H, Seidlovà-Wuttke D, Wuttke W and Köhrle J (2005) 4MBC and OMC, Components of UV-sunscreens, Exert Organ Specific Alterations on Type I 5´-Deiodinase Activity and Expression in Female Rats. 49. Symposion der DGE 09.03.2005 - 12.03.2005; Exp Clin Endocrinol Diabetes 2005; 113

Schmutzler C, Hamann I, Mentrup B, Huhne K, Topp M, Seidlovà-Wuttke D Wuttke W, and Köhrle J (2004) Endocrine disrupting UV screens alter type I 5’-deiodinase expression and activity and serum thyroid hormone levels in the rat. Turkish Journal of Endocrinology and Metabolism 8, p. 42

Kovacs G., Hofmann P. J., Hamann I., Schmutzler C., Wuttke W., Jarry H. and. Köhrle J (2004) Endocrine disrupters alter expression of the thyroid hormone-responsive genen malic enzyme in female rats. Experimental and Clinical Endocrinology and Diabetes 112, Suppl. 1, S70

Schmutzler C., Ambrugger P., Huhne K., Grüters A. and Köhrle J. (2004) Endocrine disrupters inhibit human thyroid peroxidase. Experimental and Clinical Endocrinolog and Diabetes 112, Suppl. 1, S54

Salazar V,  Castillo C, Ariznavarreta C,  Campon F,  Tresguerres J. 2004  Effect of oral intake of dibutyl phthalate on reproductive parameters of Long Evans rats and pre-pubertal development of their offspring, Toxicolgoy 205:131-137

Schmutzler C, Hoang-Vu C, Schreck R, Bienert K,  Köhrle J. 2004 Human thyroid carcinoma cell lines show different retinoid receptor repertoires and retinoid responses. Europ J Endocrinol 150: 547-556

Schmutzler,C. Hamann, I., Hofmann, P, Kovacsa, G., Stemmler, Mentrupa, B., Schomburg, L, Ambrugger,. P, Grüters b, Seidlova-Wuttke,D.,  Jarry,H ,Wuttke, W., Koehrle,J. 2004 Endocrine active compounds affect thyrotropin and thyroid hormone levels in serum as well as endpoints of thyroid hormone action in liver, heart and kidney. Toxicology 205:95-102

Boelen A, Kwakkel J, Platvoet - ter Schiphorst M, Mentrup B, Baur A, Köhrle J, Wiersinga WM. 2004 Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of Nonthyroidal Illness mainly via the central part of the hypothalamus-pituitary-thyroid axis. Eur J Endocrinol.151:497-502

Seidlova-Wuttke,D.  Jarry, H., Wuttke W. 2004 Pure estrogenic effect of benzophenone-2 (BP2) but not of bisphenol A (BPA) and dibutylphtalate (DBP)in uterus, vagina and bone. Toxicology 205:103-112

Jarry,H.,  Christoffel, J., Rimoldi, G.,  Koch, L., Wuttke, W- 2004  Multi-organic endocrine disrupting activity of the UV screen benzophenone 2 (BP2) in ovariectomized adult rats after 5 days treatment. Toxicology 205:87-93

Schlecht C, Klammer H, Jarry H, Wuttke W. 2004 Effects of estradiol, benzophenone-2 and benzophenone-3 on the expression pattern of the estrogen receptors (ER) alpha and beta, the estrogen receptor-related receptor 1 (ERR1) and the aryl hydrocarbon receptor (AhR) in adult ovariectomized rats. Toxicology 205:123-130

Gubbay O, Guo W, Rae MT, Niven D, Howie AF, McNeilly AS, Xu L and Hillier SG. 2004 Anti-inflammatory and proliferative responses in human and ovine ovarian surface epithelial cells. Reproduction. 128(5):607-614.

Schlumpf M, Jarry H, Wuttke W, Ma R, Lichtensteiger W 2004 Estrogenic activity and estrogen receptor b binding of the UV filter 3-benzylidene camphor. Comparison with 4-methylbenzylidene camphor. Toxicology 199: 109-120

Schlumpf M, Schmid P, Durrer S, Conscience M, Maerkel K, Henseler M, Gruetter M, Herzog I, Reolon S, Ceccatelli R, Faass O, Stutz E, Lichtensteiger W 2004 Endocrine activity and developmental toxicity of cosmetic UV filters - an update. Toxicology 205:113-122

Jarry, H., Gamer A, Wuttke W. 2004 Effects of 5-day styrene inhalation on serum LH and testosterone levels and on hypothalamic and striatal aminoacid neurotransmitter concentrations in male rats. Inhalation Toxicology 16: 209-215

Roy P, Salminen H, Koskimies P, Simola J, Smeds A, Saukko P and Huhtaniemi IT. 2004 Screening of some anti-androgenic endocrine disruptors using a recombinant cell-based in vitro bioassay. J Steroid Biochem Mol Biol ; 88: 157-166.

Rahman N.A. and Huhtaniemi I.T.: Testicular cell lines. 2004 Mol Cell Endocrinol, in press

Boelen A, Kwakkel J, Platvoet D, Schiphorst M, Baur A, Köhrle J, Wiersinga WM. 2004 Contribution of Interleukin-12 to the pathogenesis of nonthyroidal illness. Horm Metab Res 3:101-6

Köhrle J 2004 Thyroid hormone metabolism In: Encyclopedia of Endocrinology and Endocrine Diseases. Ed. in Chief: Martini L, Section ed. Wiersinga WM, Acad. Press/Elsevier (in press)

Seidlová-Wuttke, D., Hesse, O., Jarry, H., Christoffel, V., Spengler, B., Becker, T., Wuttke, W. 2003 Evidence for SERM activity in a Black Cohosh (Cimicifuga racemosa) extract: Comparison with estradiol-17ß. European Journal of Endocrinology 149:351-362

Köhrle J, Jakob F, Contempré B, Dumont JE. 2003 Selenium, the Thyroid, and the Endocrine System Endocrine Reviews invited review, in revision)

Ma R, Cotton B, Lichtensteiger W, Schlumpf M.2003 UV filters with antagonistic action at androgen receptors in the MDA-kb2 cell transcriptional-activation assay. Toxicol. Sci. 74: 43-50

Wuttke, W., Jarry, H., Becker, T., Schultens, A., Christoffel, V., Gorkow, C., Seidlová-Wuttke, D. 2003 Phytoestrogens: Endocrine disrupters or replacement for hormone replacement therapy? Maturitas 44:S9-20

Brtko J, Bobadova J, Podoba J, Schmutzler C, Köhrle J. 2002 Thyroid hormone receptors and type I iodothyronine 5'-deiodinase activity of human thyroid toxic adenomas and benign cold nodules Exp Clin Endo & Diabetes 110:166-170

Schmutzler C, Schmitt TL, Glaser F, Köhrle J, Loos U. 2002 The promoter of the human sodium/iodide-symporter gene responds to retinoic acid. Mol. Cell. Endo 189:145-155

Hoang-Vu C, Boltze C, Poremba C, Dockhorn-Dworniczak B, Köhrle J, Schmutzler C, Rath FW, Dralle H. 2002 Expression and regulation of telomerase genes in thyroid carcinoma. Int J Oncol 21:265-272

Baur A, Buchfelder M, Köhrle J. 2002 Expression of 5’-deiodinase enzymes in normal pituitaries and various human pituitary adenomas. Eur. J. Endo 147:263-268

Simon D, Körber C, Krausch M, Segering J, Groth P, Görges, Grünwald, Müller-Gärtner, Schmutzler C, Köhrle J, Röher HD, Reiners C. 2002 Clinical impact of retinoids in redifferentiation therapy of advanced Thyroid cancer – final results of a Pilot study Eur. J. Nucl. Med. Mol. Imaging 29:775-782

Köhrle J 2002 Iododthyronine Deiodinases In: Methods in Enzymology Vol. 347, Academic Press, New York, pp. 125-167

Zimmermann MB, Köhrle J. 2002 The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health. Thyroid 12:867-878

Abstracts

Jarry H., Schlecht C., Klammer H., Wuttke W. Effects of the putative Xenoestrogenes Benzophenone-2 (BP2) and Octyl-methoxycinnamate (OMC) on pituitary and uterine gene expression in the rat, (DGE) in Münster, March 9-11 2005

Seidlová-Wuttke D., Stolze M., Vossmann V., Wuttke W. Effects of 3 estrogenic UV filters on bone in ovariectomized rats, (DGE) in Münster, March 9-11 2005

Gubbay O, Rae MT, Zeleznik AJ and Hillier SG (2005) Differential effects ofCREB (cAMP responsive element binding) protein expression between normalovarian surface epithelial cells and cell lines derived from ovarian cancers. British Endocrine Society, Harrogate, UK 2005.

Gubbay O , Rae MT, Saunders PT and Hillier SG. (2004) Analysis of endocrine disruptors using luciferase reporter systems in cell lines and primary cultures of human ovarian surface epithelial (OSE) cells. EURISKED / CREDO Cluster Workshop, Mallorca, Spain 2004.

Gubbay O, Guo W, Rae MT, Niven D, Langdon SP and Hillier SG. (2004) Comparison of IL-1a induced gene expression in normal human ovarian surface epithelial cells and ovarian cancer cells. British Endocrine Society Conference, Brighton, UK 2004.

Gubbay O, Guo W, Rae M, Zeleznik AJ and Hillier SG. Use of an adenoviral transfection system to study signalling pathways involved in growth and death of ovine ovarian surface epithelial cells. Society for the Study of Fertility, AnnualConference Aberdeen, UK 2003.

Schlumpf M, Durrer S, Maerkel K, Ma R, Conscience M, Haller V, Furrer M, Gruetter M, Herzog I, Tschopp R, Lichtensteiger W            2003  Endocrine activity and developmental toxicity of UV filters  European Sunfilter Conference, Paris, Proceedings   CD

Schlumpf M, Durrer S, Maerkel K, Conscience M, Ma R, Lichtensteiger W 2003 Endocrine activity of UV filters and effects on development of reproductive organs, brain and gene expression            SETAC Europe 13th Annual Meeting, Hamburg Abstracts p. 184-185 (WEP/104

Schlumpf M, Durrer S, Maerkel K, Conscience M, Fleischmann I, Ma R, Lichtensteiger W 2003 Endocrine activity and developmental toxicity of UV filters Toxicologist 72 S-1: 133-134 (no. 649)

Gaille, C., Lichtensteiger, W., Schlumpf, M. (2005). Endocrine activity of UV filters in immature rat uterus/ovary at the level of organ weight and gene expression following multiple (3 doses) or acute single dosages. USGEB Meeting 2005 (Union of Swiss Societies for Experimental Biology), Zurich, 2005, Abstract